Oliver Werz Selected Research

Arachidonate 5-Lipoxygenase (5 Lipoxygenase)

1/2022	Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201.
11/2021	Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators.
6/2021	From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution.
10/2020	Exotoxins from Staphylococcus aureus activate 5-lipoxygenase and induce leukotriene biosynthesis.
10/2019	Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors.
1/2019	Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase.
10/2018	Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
8/2018	Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.
7/2018	Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation.
1/2018	Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Oliver Werz Research Topics

Disease

80	Inflammation (Inflammations) 05/2022 - 10/2005
39	Neoplasms (Cancer) 03/2022 - 01/2006
18	Peritonitis 01/2022 - 11/2013
18	Asthma (Bronchial Asthma) 01/2022 - 03/2002
10	Pleurisy (Pleuritis) 01/2017 - 04/2009
8	Infections 03/2022 - 01/2012
8	Atherosclerosis 01/2020 - 12/2005
7	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 04/2009
6	Carcinogenesis 01/2020 - 04/2009
6	Edema (Dropsy) 10/2019 - 04/2009
6	Pain (Aches) 07/2019 - 03/2010
6	Hypersensitivity (Allergy) 05/2017 - 08/2005
5	Wounds and Injuries (Trauma) 05/2022 - 12/2018
4	Arthritis (Polyarthritis) 01/2021 - 10/2018
3	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 09/2014
3	Mitochondrial Diseases (Mitochondrial Disease) 11/2020 - 11/2015
3	Alzheimer Disease (Alzheimer's Disease) 02/2015 - 06/2010
2	Bacterial Infections (Bacterial Infection) 01/2022 - 10/2020
2	Tuberculosis (Tuberculoses) 10/2021 - 01/2020
2	Sepsis (Septicemia) 05/2021 - 01/2018
2	Rheumatoid Arthritis 01/2021 - 01/2018
2	Relapsing-Remitting Multiple Sclerosis 01/2020 - 01/2018
2	Foodborne Diseases 12/2019 - 01/2019
2	Hyperalgesia 07/2019 - 01/2017
2	Gout 10/2018 - 10/2018
2	Shock 08/2017 - 07/2011
2	Fever (Fevers) 11/2015 - 03/2011
2	Leukemia 01/2015 - 01/2003
2	Carcinoma (Carcinomatosis) 08/2009 - 05/2009
1	Colonic Neoplasms (Colon Cancer) 03/2022
1	Metabolic Diseases (Metabolic Disease) 01/2022

Drug/Important Bio-Agent (IBA)

36	LeukotrienesIBA 01/2022 - 03/2002
29	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2022 - 08/2005
28	LipidsIBA 05/2022 - 04/2008
18	ProstaglandinsIBA 01/2022 - 09/2008
17	EnzymesIBA 01/2022 - 07/2006
16	Dinoprostone (PGE2)FDA Link 01/2022 - 05/2009
16	ZymosanIBA 01/2022 - 11/2013
14	Pharmaceutical PreparationsIBA 01/2022 - 09/2008
14	CarrageenanIBA 07/2019 - 04/2009
11	Biological ProductsIBA 01/2022 - 01/2006
11	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2022 - 08/2009
10	EicosanoidsIBA 06/2021 - 01/2012
10	Leukotriene B4IBA 10/2020 - 04/2009
8	CytokinesIBA 01/2022 - 04/2008
8	Arachidonic Acid (Vitamin F)IBA 12/2019 - 01/2003
7	Prostaglandins EIBA 07/2012 - 08/2009
6	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 05/2022 - 01/2020
6	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2012
5	myrtucommulone AIBA 03/2022 - 01/2015
5	LipoxygenasesIBA 01/2022 - 09/2012
5	FrankincenseIBA 07/2021 - 06/2014
5	AcidsIBA 06/2021 - 06/2011
5	Adenosine Triphosphatases (ATPase)IBA 01/2019 - 10/2014
4	AndrogensIBA 01/2021 - 12/2008
4	Prostaglandin-E SynthasesIBA 01/2016 - 07/2014
3	CelluloseIBA 05/2022 - 05/2020
3	AllergensIBA 01/2022 - 01/2019
3	Vitamin E FDA LinkGeneric 01/2022 - 01/2018
3	LipopolysaccharidesIBA 05/2021 - 05/2009
3	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2021 - 01/2020
3	Glutathione (Reduced Glutathione)IBA 01/2021 - 01/2018
3	OxylipinsIBA 12/2019 - 12/2018
3	CurcuminIBA 12/2015 - 08/2009
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2015 - 06/2010
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 05/2022 - 10/2021
2	Anti-Bacterial Agents (Antibiotics)IBA 03/2022 - 07/2019
2	hyperforinIBA 03/2022 - 11/2015
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2022 - 06/2010
2	Lipoxygenase (Lipoxygenase-1)IBA 01/2021 - 01/2019
2	Glycogen Synthase KinasesIBA 10/2020 - 05/2014
2	ResveratrolIBA 10/2019 - 11/2014
2	Analgesics (Analgesic Drugs)IBA 07/2019 - 01/2017
2	LignansIBA 01/2019 - 08/2011
2	MK-886IBA 08/2017 - 04/2009
2	Platelet Activating FactorIBA 08/2017 - 07/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017 - 04/2009
2	Proton-Translocating ATPases (ATPase, H+)IBA 01/2017 - 10/2014
2	Protons (Proton)IBA 01/2017 - 10/2014
2	Peroxidase (Myeloperoxidase)IBA 04/2016 - 04/2009
2	Cytochromes c (Cytochrome c)IBA 11/2015 - 01/2008
2	Interleukin-6 (Interleukin 6)IBA 08/2015 - 10/2014
2	pretubulysinIBA 08/2014 - 03/2014
2	Therapeutic UsesIBA 06/2012 - 10/2005
2	Prostaglandin H2 (PGH(2))IBA 03/2011 - 08/2009
2	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 12/2006 - 03/2002
1	CarbohydratesIBA 05/2022
1	PolymersIBA 05/2022
1	Biocompatible Materials (Biomaterials)IBA 05/2022
1	Antiviral Agents (Antivirals)IBA 03/2022
1	CateninsIBA 03/2022
1	Prostaglandin H2 Thromboxane A2 ReceptorsIBA 01/2022
1	Epoxide HydrolasesIBA 01/2022
1	Sulfasalazine (Azulfidine)FDA LinkGeneric 01/2022
1	celastrolIBA 01/2022
1	GlucocorticoidsIBA 01/2022

Therapy/Procedure

12	Therapeutics 01/2022 - 03/2002
7	Drug Therapy (Chemotherapy) 01/2022 - 01/2017
4	Traditional Medicine (Folk Remedies) 03/2022 - 01/2012
2	Oral Administration 01/2022 - 01/2018